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All treatments

Radiopharmaceutical Therapy

Radiation given as a medicine, which travels to the cancer itself.

Instead of aiming a beam from outside, the treatment is given as an injection or a capsule. It circulates and collects where the disease is, and treats it from there. This is offered at our Fort Worth center.

  • Fort Worth only
  • Injection or capsule
  • Safety precautions apply
Diagram of radiopharmaceutical therapy: a radioactive medicine travelling through the body and collecting at deposits in bone

Why it is used

What this kind of treatment does well.

It goes looking for the disease

The drug is chosen because the body sends it where the cancer is, so it can reach several sites at once rather than one target at a time.

It concentrates where it lands

The radiation travels only a very short distance from where the drug settles, so the dose falls away sharply outside that area.

Few visits, not weeks of them

Nothing here is a daily course. Iodine treatment is usually a single administration; radium is given as a small number of appointments spaced weeks apart.

Often about how you feel

For cancer that has spread to bone, reducing pain and keeping you on your feet is a legitimate goal in itself, and is often the point.

In plain words

The radiation arrives from the inside.

A radioactive substance is attached to something your body already handles in a predictable way. Give it, and the body carries it to the tissue that takes that substance up. Radium behaves chemically like calcium, so it collects where bone is actively repairing itself, which is exactly where secondary deposits are. Iodine is taken up mainly by thyroid tissue and by thyroid cancer cells, which is what makes it useful, though the salivary glands take up some as well, and that is why a dry mouth is one of the things to expect.

Once it is there, the radiation it gives off travels a very short distance, so it treats the tissue it has landed in and spares most of what surrounds it. You are not treated on a machine and there is no beam. You have an injection or swallow a capsule, and the treatment happens over the following days.

That is also the reason these treatments carry precautions that external beam radiation does not. External beam stops when the machine switches off; this carries on until the medicine decays and is cleared. How much that restricts you depends on which one you have, and the difference is large, so it is set out for you specifically rather than in general terms.

How it works

From assessment to going home.

  1. Assessment

    Not everyone is suitable, and this is decided properly rather than assumed. Your scans, your blood counts and your general health all bear on it, and so does what other treatment you are having or about to have.

  2. Planning the practical side

    Before anything is given you are told what precautions apply, for how long, and what that means at home. If you live with young children or someone who is pregnant, say so at this appointment rather than afterwards.

  3. The treatment itself

    An injection or a capsule, given at our Fort Worth center. The administration takes minutes. There is no anesthetic and nothing to lie still inside.

  4. The days afterwards

    You follow the precautions you were given. After radium-223 those are essentially bathroom hygiene and hand washing for about a week, with no need to keep away from anyone. After iodine-131 they do include keeping a real distance from other people for a number of days. Either way they are time-limited and written down for you.

  5. Repeat and review

    Some of these treatments are given as a course of several doses spaced weeks apart, with blood tests in between. You are reviewed between doses rather than simply booked in for the next one.

A man in his sixties filling a kettle at the sink in his own kitchen in the morning

You go home the same day.

For most of these treatments there is no hospital stay. There are some rules to follow for a few days, and they are explained to you in advance rather than handed over on the way out.

Who it is for

This may be worth discussing if:

  • You have prostate cancer that has spread to bone and is causing pain
  • You have had surgery for thyroid cancer and need treatment to what remains
  • Disease is in several places at once, so treating one site at a time is not the answer
  • You are well enough for treatment but would struggle with weeks of daily visits

This is not a treatment anyone should self-select into. It depends on the type of cancer, on where it has spread, on your blood counts and on what other treatment you are having or about to have. Your radiation oncologist works this out with your medical oncologist or your endocrinologist rather than in isolation.

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Questions

What people ask about radiopharmaceutical therapy.

Will I be radioactive? Can I be around my family?

For a period, yes, and this is the honest difference between this treatment and external beam radiation, where nothing stays behind. But how much it affects your family life depends enormously on which treatment you have, and the two are not alike. After radium-223 for bone metastases, the radiation travels less than a tenth of a millimetre, so it does not reach anybody standing next to you: there is normally no need to keep your distance from anyone, including children, and the precautions are about bathroom hygiene and washing your hands for about a week. Iodine-131 is different, because it does give off radiation that leaves your body, and it does mean keeping a real distance from other people for a number of days, particularly young children and anyone pregnant. You will be given the precautions that actually apply to you, in writing, before you agree to anything, and if they are difficult at home we would rather sort that out beforehand than have you find out afterwards.

What are the side effects?

They depend on which treatment you have. Common ones include tiredness, nausea, and a fall in blood counts, which is why blood tests are done between doses. Treatment to the thyroid can cause a dry or sore mouth and a change in taste. Some effects appear later rather than during treatment, and a small number are lasting. Your oncologist will go through the ones that apply to your treatment and how likely each is before you consent to it.

Is this chemotherapy?

No. It is radiation, delivered as a medicine rather than as a beam. It is given by a different route from chemotherapy, works in a different way and has a different pattern of side effects, although some, such as tiredness and an effect on blood counts, overlap.

Is it a cure?

It depends entirely on the situation. After surgery for thyroid cancer, iodine treatment is given with the intention of clearing what remains. For prostate cancer that has spread to bone, the aim is usually to control the disease and reduce pain rather than to cure it, and that is a real and worthwhile aim. Anyone who tells you which of these applies to you without knowing your case is guessing.

Do I have to stay in hospital?

For most of these treatments, no, and you go home the same day. Some higher-dose iodine treatments do require a short stay in a room set aside for it. You will know which applies to you well before the day, because it changes what you need to arrange.

Why only Fort Worth?

Handling and giving a radioactive medicine needs facilities and licensing that sit at our Fort Worth center. If you usually come to Arlington and this treatment is right for you, your care is coordinated between the two rather than started again from the beginning. Call either number and we will sort out where you need to be.

Patient stories

In their words.

Dr. Lanasa put me at ease immediately and was zeroed on me at each weekly visit during my eight weeks of therapy. His bedside manner is that of a caring and concerned doctor. Staff, like Dr. Lanasa is second to none.
Verified patient Arlington, TX via Vitals, June 2019
Above Excellent. This man spent literally 2 hours, explaining to me my treatment plan. He is an extremely optimistic inspiring and informative physician. Extremely compassionate. We need more Doctors like him. Thank you so much.
Verified patient Fort Worth, TX via Vitals, February 2020
I am so happy I picked Dr. Barker as my husband's doctor. When we learned my husband oral cancer we were shocked and lost about how to start treatment. Dr. Barker was the first doctor we saw and he led us to my husband's surgeon and oncologist. Dr. Barker explained everything to us and answered all our questions. He is the most wonderful doctor. When a family has to go through cancer it make so much easier when you have a doctor like Dr. Barker. He really cares about his patients and their family.
Verified patient Fort Worth, TX via Vitals, March 2013

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This page is for information and is not medical advice. These treatments are only suitable for particular cancers and particular patients, and the precautions that apply depend on which one you are given. Please talk to a qualified physician about your own condition.

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